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Færslur: 2011 Febrúar16.02.2011 09:25Frábærar fréttirFrábærar fréttir Búið er að DNA prufa Leirdals Fagurklukku fyrir PRA og FN (Familial Nephropathy ) Niðurstöður eru komnar í hús og hún er OPTIGEN A NORMAL/CLEAR OG FN CLEAR !!! Þetta er bestu fréttir fyrir okkar ræktun og þetta þýðir að gotið undan Fjólu og Britten er CLEAR by parentige! Britten er einnig OPTIGEN A OG FN CLEAR. Leirdals Fagurklukka "Fjóla" er fyrsti enski cockerinn sem fæddur er á íslandi sem er DNA prufaður fyrir þessu. Leirdals Fagurklukka "Fjóla" Arfgeng, vaxandi sjónurýrnun (Progressiv Retinal Atrofi/PRA)Vaxandi sjónurýrnun er mjög alvarlegur og arfgengur sjúkdómur í sjónunni sem veldur blindu. Ástæðan er sú að æðarnar í sjónunni rýrna - og hverfa að lokum svo hún fær enga næringu og rýrnar líka.Fyrstu einkenni arfgengrar, vaxandi sjónurýrnunar er náttblinda sem með tímanum veldur algjörri blindu.Sjúkdómurinn sem er sársaukalaus og ólæknanlegur, er þekktur í mörgum hundategundum, en það er hins vegar mismunandi eftir tegund á hvaða aldri einkenni hans koma í ljós. Á myndunum þremur sjást heilbrigðar, æðaríkar sjónur frá mismunandi hundategundum! Og hér eru tvær svo tvær óheilbrigðar sjónur:
Staðfesting sjúkdómsins fæst með augnskoðun
en einnig er mögulegt í sumum hundategundum að staðfesta hann, eða
útiloka, með DNA greiningu . Tekið af heimasíðu Helgu Finns dýralæknis Fn (Familial Nephropathy
) Familial Nephropathy
(FN) is a recessively inherited (Lees, Macdougall/Cattanach) renal disease
that has been recognized in the English Cocker for more than 50 years (Krook
162). FN is a form of "hereditary nephritis" (Lees 189) which refers to a
group of glomerular diseases that are linked to genetic collagen defects. Structure/Function The kidney is an organ
made up of hundreds of thousands of tiny structures called nephrons. Each
nephron consists of a glomerulus and a tubule. Blood flowing through the
kidney is filtered by the glomerulus, with the fluid that is filtered out
of the blood subsequently passing down the length of the tubule. Cells that
line the inner surface of the tubule process the fluid as it flows along,
reabsorbing certain components of the fluid and excreting others. The fluid
leaving the tubule at the end of this process is urine, which is a combination
of water and waste products. In the Beginning... English Cockers affected with FN are born with normally developed kidneys. Because they lack a certain type of collagen, however, the kidneys begin to deteriorate while the dogs are just a few months old. As glomerular damage evolves, the kidneys will first allow protein (proteinuria) to escape into the urine. Generally, while proteinuria persists, the pup's growth rate will slow down. Once the pup begins to spill protein into the urine, the ability of the kidneys to 'concentrate' the urine will also diminish. Finally, as a result of progressive nephron damage, the ability of the kidneys to excrete waste products (eg, urea and creatinine) will become impaired (Lees). As excretion of waste products by the kidneys progressively diminishes, the severity of renal failure will gradually worsen. Sequence of Events The sequence of events is always the same, but the rate of disease progression varies for reasons that are not fully understood (Lees). As a result, it is difficult to give a specific age when to expect various stages of the disease to take place. "For example, onset of proteinuria was at 5 to 8 months of age in 3 dogs in which it was carefully studied. Because we can't be sure that these 3 dogs are representative of all FN-affected dogs, we are uncertain what age to say is the oldest an FN-affected dog can be when it first has proteinuria. Nonetheless, we suspect that all, or almost all, dogs with FN will have proteinuria before a year of age. The age range for occurrence of renal failure is 6 months to 2 years" (Lees). Clinical Signs One way to identify a pup that might have FN is through observation. Breeders and owners can watch the voiding patterns of young dogs. Make it a point to regularly check the color of the urine. The first morning release (assuming water hasn't been available during the night) is probably best. There should be good yellow color (well concentrated). A youngster that lacks the ability to pass concentrated urine repeatedly should be taken to a veterinarian for a complete urinalysis. A test called a "specific gravity (SG)" should be performed as well as an analysis for protein (proteinuria). Usually, protein can be checked by using a color-coded plastic strip (Bili-Labstix). This strip is merely dipped into a urine specimen and the plastic strip changes color and is checked against a chart on the side of the bottle the strips come in. This strip will test for several things other than protein. A pup with a low specific gravity and excess protein (++) in the urine should be tested using a more specific test. This test, a 'protein-creatinine ratio,' will provide a better estimate of the amount of protein in the urine. A complete urinalysis should also be done to identify other urinary problems that may be present. A positive dip-stick for protein does not necessarily indicate that the dog has renal disease or will develop FN. It's merely an indication that a more thorough evaluation is needed. Not all young-age renal failure in this breed is FN; however, the symptoms are the same. End Stage Once it is established
that a young dog is consistently passing dilute urine with protein, serum
chemistry tests should be performed. Such tests will only show significant
elevations in specific areas once 75% of both kidneys are destroyed. Elevations
in BUN (blood urea nitrogen), creatinine, and inorganic phosphorus suggest
kidney disease. These findings coupled with a low urine specific gravity
and proteinuria signal end-stage renal disease. Addi Pittman, Chairperson ECSCA Health Education Það er ekki skylda á Íslandi að Dna prufa enska cockerinn en okkur í Leirdals ræktun fannst okkur bera skylda til þess að gera það. Nú eru öll ræktunardýrin okkar Optigen A (Dna testuð fyrir PRA) og Britten og Fjóla einnig DNA testuð fyrir FN sjúkdómnum. Eru þetta stórkostlegar fréttir fyrir stofninn okkar og okkar línur í Leirdals ræktun. Bestu kv Þórdís Skrifað af Dísa Mæja
Flettingar í dag: 96 Gestir í dag: 28 Flettingar í gær: 515 Gestir í gær: 66 Samtals flettingar: 1552752 Samtals gestir: 200062 Tölur uppfærðar: 25.2.2021 16:34:37 clockhere
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